Biofisica - SBE Magazine --- May - August 2015

Featured

Schematic representation of lipid nanotube (NT) formation by flux-induced rolling of membrane-covered silica beads on top of a polymer micropillars array.

Microfluidic chip with pillar arrays for controlled production and observation of lipid membrane nanotubes

HomolWat is a tool for incorporating internal water molecules into GPCR structures that uses template-based modelling of homologous water molecules present in related high-resolution structures. It is available at http://lmc.uab.cat/homolwat.

HomolWat: a web server tool to incorporate 'homologous' water molecules into GPCR structures

This work describes the mechanism for binding and release of M. Genitalium pathogen to and from sialylated human receptors

Structure and mechanism of the Nap adhesion complex from the human pathogen Mycoplasma genitalium

Computational and biochemical approaches are combined iteratively to better understand how phosphorylation affects protein structure and function. In such a research workflow, Molecular Dynamics simulations emerge as a key decision-making tool for designing the most appropriate strategy to be used in the lab

Exploring protein phosphorylation by combining computational approaches and biochemical methods

We have used high-speed AFM microscopy to follow in real time, and with single-molecule resolution, the self-assembly of the mature HIV capsid lattice. Individual protein molecules have been visualized while they associate with each other during a reversible assembly reaction that proceeds stochastically through multiple pathways.

Visualization of Single Molecules Building a Viral Capsid Protein Lattice through Stochastic Pathways

Combination of thousands of cryo-electron microscopy images (background) yields a highly detailed 3D map (top right) of human adenovirus. At the left, the structure of the major coat protein is shown fitted to the map, with empty density corresponding to the trapped lytic peptide.

Dynamic competition for hexon binding between core protein VII and lytic protein VI promotes adenovirus maturation and entry

Download Biofísica #1

Articles in this issue

Editorial

Jesus Salgado

Is Science at a “critical point”?

Jesús Salgado, ICMol (Valencia)

Reportage

Dr. Teresa Giraldez

From Tenerife to King George Island: An Antarctic Adventure

Teresa Giraldez, CIBICAN (Tenerife)

beyond Biophysics

Jesús Jiménez-Barbero, April 15 2015

Chemistry and Biophysics Conversation with Jesús Jiménez-Barbero

Jesús Salgado, ICMol (Valencia)

cool Biophysics

Professor Jesús Vázquez, Fundación Centro Nacional de Investiigaciones Cardiovasculares (Madrid)

The race towards the human proteome

Jesús Vázquez, CNIC (Madrid)