Tagged: Enzyme

Mechanism of Molecular Oxygen Diffusion in a Hypoxia-Sensing Prolyl Hydroxylase Using Multiscale Simulation. J Am Chem Soc. 2020 Feb 5;142(5):2253-2263. doi: 10.1021/jacs.9b09236.

Feb. 2020 / Highlights2020

30/03/2020

Mechanism of Molecular Oxygen Diffusion in a Hypoxia-Sensing Prolyl Hydroxylase Using Multiscale Simulation

Domene C, Jorgensen C, Schofield CJ. J Am Chem Soc 2020 Feb; 142: 2253. The chronic response of animals to hypoxia is mediated by...

Why are some Enzymes Dimers? Flexibility and Catalysis in Thermotoga Maritima Dihydrofolate Reductase. ACS Catal. 2019 Jul 5;9(7):5902-5911. doi: 10.1021/acscatal.9b01250.

Highlights2019 / Jul. 2019

06/09/2019

Why are some Enzymes Dimers? Flexibility and Catalysis in Thermotoga Maritima Dihydrofolate Reductase

Ruiz-Pernia JJ, Tuñón I, Moliner V, Allemann RK. ACS Catal 2019 Jul; 9: 5902. Dihydrofolate Reductase from Thermotoga maritima (TmDFHFR) is a dimeric thermophilic...

Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly. Nat Commun. 2019 Jun 28;10(1):2865. doi: 10.1038/s41467-019-10781-1.

Highlights2019 / Jun. 2019

25/07/2019

Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly

Cuellar J, Ludlam WG, Tensmeyer NC, Aoba T, Dhavale M, Santiago C, Bueno-Carrasco MT, Mann MJ, Plimpton RL, Makaju A, Franklin S, Willardson BM, Valpuesta...

DGA predoctoral fellowship at University of Zaragoza (BIFI) - 2019

Calls / Jobs / Predoc

09/07/2019

DGA predoctoral fellowship at University of Zaragoza (BIFI)

Deadline: July 16th, 2019. The Diputación General de Aragón (DGA) offers fellowships to carry out a PhD Thesis at the Universidad of Zaragoza (BIFI), about...

Molecular Basis of Broad Spectrum N-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2. ACS Cent Sci. 2019 Mar 27;5(3):524-538. doi: 10.1021/acscentsci.8b00917.

Highlights2019 / Mar. 2019

02/05/2019

Molecular Basis of Broad Spectrum N-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2

Klontz EH, Trastoy B, Deredge D, Fields JK, Li C, Orwenyo J, Marina A, Beadenkopf R, Gunther S, Flores J, Wintrode PL, Wang LX, Guerin...

Ferredoxin-linked flavoenzyme defines a family of pyridine nucleotide-independent thioredoxin reductases. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):12967-12972. doi: 10.1073/pnas.1812781115.

Dec. 2018 / Highlights2018

22/01/2019

Ferredoxin-linked flavoenzyme defines a family of pyridine nucleotide-independent thioredoxin reductases

Buey RM, Fernandez-Justel D, de Pereda JM, Revuelta JL, Schurmann P, Buchanan BB, Balsera M. Proc Natl Acad Sci U S A 2018 Dec;...

Postdoc

08/01/2019

Postdoctoral Positions at the University of Zaragoza (Juan de la Cierva 2019)

DEADLINE: January, 21st , 2019 The Spanish Ministry of Science, Innovation and Universities has announced the 2018 call to support 2-year postdoctoral contracts at Universities...

Conformational entropy of a single peptide controlled under force governs protease recognition and catalysis. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11525-11530. doi: 10.1073/pnas.1803872115.

Highlights2018 / Nov. 2018

12/12/2018

Conformational entropy of a single peptide controlled under force governs protease recognition and catalysis

Guerin ME, Stirnemann G, Giganti D. Proc Natl Acad Sci U S A 2018 Nov; 115: 11525. An immense repertoire of protein chemical modifications...

Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria. Sci Transl Med. 2018 Sep 19;10(459). pii: eaat7467. doi: 10.1126/scitranslmed.aat7467.

Highlights2018 / Sep. 2018

18/10/2018

Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria

Urquiza P, Lain A, Sanz-Parra A, Moreno J, Bernardo-Seisdedos G, Dubus P, Gonzalez E, Gutierrez-de-Juan V, Garcia S, Erana H, San Juan I, Macias I,...

All Articles / cool Biophysics

06/10/2018

Ancestral proteins: How and why

Ancestral proteins: How and why Jose M. Sánchez-Ruiz & Valeria A. Risso, Univ. Granada, Granada (Spain). download Strictly speaking, ancestral proteins are proteins from extinct...

DGA predoctoral fellowship at University of Zaragoza (BIFI)

Calls / Fellowships / Jobs / Predoc

06/09/2018

DGA predoctoral fellowship at University of Zaragoza (BIFI)

The “Diputación General de Aragón” – DGA offers fellowships to carry out a PhD Thesis on the molecular recognition of GalNAc-Ts and other glycosyltransferases on...