Macromolecular assemblies at the crossroads of cell stress and function

EMBO | Workshop: Macromolecular assemblies at the crossroads of cell stress and function. 31 May – 4 June 2015, Jerusalem (Israel).

Workshop Web Site: Follow this Link

Recent work has highlighted the sub-organellar meso-scale of protein organization has gained increasing attention as an essential mediator of protein folding, function, proteostasis, transcription, translation, and RNA metobolism. In particular, stress-induced RNP granules and protein inclusions are emerging as essential elements of the quality control architecture on one hand, and causal agents of several age-associated diseases on the other hand. These nano-scale macromolecular assemblies (or Dynamic Droplets) provide a platform for rapid protein and nucleic acid transport, and for rapid response to changing conditions, but can also serve as targets for pertrubation by dysfunctional proteins…

Topics

• RNP granules in RNA quality control and dynamics
• Meso-scale organization of protein mixtures and phase transitions in the cytoplasm
• Aggregation, stress, and brain diseases
• RNA and Neurodegeneration
• Cellular architecture of protein quality control and aggregation
• Aging, replicative rejuvenation, and asymmetric inheritance
• Inclusions in cellular regulation and disease
• Protein degratation in proteostasis and quality control

Deadlines

• 15 February 2015, Early registration
• 1 April 2015, Late registration and Abstract submision

More information

• Find more information in the Workshop Web Site.
• See here a complete list of 2015 EMBO Events.