3 Postdoc Positions – Protein Mechanics – Columbia University (New York)
Single molecule techniques to understand the dynamics of proteins under force
The Single Protein Mechanics and Engineering laboratory of Columbia University in the City of New York, USA is seeking highly motivated candidates for three postdoctoral research positions.
Our work focuses on using single molecule techniques to understand the dynamics of proteins under force. We use AFM and Magnetic Tweezers techniques to apply force to engineered protein constructs and measure their unfolding, collapse and folding behavior. We also study how chemical reactions such as disulfide bond reduction depend on mechanical forces.
Resources and Projects
The laboratory is interdisciplinary and attracts an eclectic mixture of biologists, physicists, engineers and chemists who share an interest in developing the new field of mechanical biochemistry. It is a fully equipped to engineer a wide range of protein constructs for our single molecule experiments.
In addition, lab members build their our single molecule instruments, write all their software and develop their own mechanical models.
Funded by NIH and NSF grants, the laboratory is focused on understanding three systems at the molecular level; the elasticity of the giant muscle protein Titin, the mechanical design of the Pili of gram-positive bacteria and the Talin/Vinculin force transduction system.
Apart from advancing knowledge in this new field of science, the lab projects also aim at exploring the medical significance of their findings.
Columbia University provides access to housing near the campus, health care, and competitive salaries.
Send your application to Prof. Julio M. Fernandez with the heading “Post doctoral Position”.