Why are some Enzymes Dimers? Flexibility and Catalysis in Thermotoga Maritima Dihydrofolate Reductase

Why are some Enzymes Dimers? Flexibility and Catalysis in Thermotoga Maritima Dihydrofolate Reductase. ACS Catal. 2019 Jul 5;9(7):5902-5911. doi: 10.1021/acscatal.9b01250.
Why are some enzymes dimers? Based on a theoretical simulation on dihydrofolate reductase of different organisms, the present study provides evidences on how dimerization, despite provoking a reduced catalytic efficiency, provides two advantages for termophile organisms: it protects its structure against denaturation and it provides a less negative activation entropy, toning down the increase of the activation free energy with temperature.