Role of Zinc and Magnesium Ions in the Modulation of Phosphoryl Transfer in Protein Tyrosine Phosphatase 1B
Bellomo E, Abro A, Hogstrand C, Maret W, Domene C. J Am Chem Soc 2018 Mar; 140: 4446. While the majority of phosphatases are...
Tagged: Enzyme
Insights on the Origin of Catalysis on Glycine N-Methyltransferase from Computational Modeling
Swiderek K, Tunon I, Williams IH, Moliner V. J Am Chem Soc 2018 Mar; 140: 4327. The origin of enzyme catalysis remains a question...
Isotope Substitution of Promiscuous Alcohol Dehydrogenase Reveals the Origin of Substrate Preference in the Transition State
Behiry EM, Ruiz-Pernia JJ, Luk L, Tunon I, Moliner V, Allemann RK. Angew Chem Int Ed Engl 2018 Mar; 57: 3128. The origin of...
DGA and FPU predoctoral fellowships at University of Zaragoza (BIFI)
The group of Dr. Ramón Hurtado-Guerrero offers two predoc positions to work on the molecular recognition of GalNAc-Ts on protein substrates at The Institute for...
High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center
Baños-Mateos S, van Roon AM, Lang UF, Maslen SL, Skehel JM, Lamers MH. Nat Commun 2017 Oct; 8: 855. High-fidelity DNA replication depends on...
Structure-based domain assignment in Leishmania infantum EndoG: characterization of a pH-dependent regulatory switch and a C-terminal extension that largely dictates DNA substrate preferences
Oliva C, Sanchez-Murcia PA, Rico E, Bravo A, Menendez M, Gago F, Jimenez-Ruiz A. Nucleic Acids Res 2017 Sep; 45: 9030. Mitochondrial endonuclease G...
FPI-MINECO predoctoral fellowship at University of Zaragoza (BIFI)
The Spanish Ministry of Economy and Competitiveness – MINECO offers a predoc fellowship (former FPI) to carry out a PhD Thesis on “GalNAc-Ts molecular recognition...
De novo active sites for resurrected Precambrian enzymes
Risso VA, Martinez-Rodriguez S, Candel AM, Kruger DM, Pantoja-Uceda D, Ortega-Munoz M, Santoyo-Gonzalez F, Gaucher EA, Kamerlin SCL, Bruix M, Sanchez-Ruiz JM. Nat Commun...
Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa
Acebron I, Mahasenan KV, De Benedetti S, Lee M, Artola-Recolons C, Hesek D, Wang H, Hermoso JA, Mobashery S. J Am Chem Soc 2017...
Structural basis of human PCNA sliding on DNA
De March M, Merino N, Barrera-Vilarmau S, Crehuet R, Onesti S, Blanco FJ, De Biasio A. Nat Commun 2017 Jan.; 8: 13935. Sliding clamps...
FPI-MINECO Fellowship at Structural Biology Unit – CIC bioGUNE
4 years Ph.D. position funded by FPI-MINECO from 2017 to 2020 The position is currently available at the Structural Glycobiology Group, Structural Biology Unit, CIC...
Pastrana…Moreno-Herrero {Nucleic Acids Res 44: 8885}
Force and twist dependence of RepC nicking activity on torsionally-constrained DNA molecules Pastrana CL, Carrasco C, Akhtar P, Leuba SH, Khan SA, Moreno-Herrero F. Nucleic...