Molecular Basis of Broad Spectrum N-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2

Molecular Basis of Broad Spectrum N-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2. ACS Cent Sci. 2019 Mar 27;5(3):524-538. doi: 10.1021/acscentsci.8b00917.
Schema of the hydrolysis reaction catalyzed by EndoS2 secreted on IgG antibodies. Surface representation of EndoS2 indicating the domains involved in the activity of the enzyme, the glycosidase hydrolase, and carbohydrate binding module domains.