Torreira…Llorca {Structure 23: 183}
Amyloidogenesis of Bacterial Prionoid RepA-WH1 Recapitulates Dimer to Monomer Transitions of RepA in DNA Replication Initiation.
Torreira E, Moreno-Del Álamo M, Fuentes-Perez ME, Fernández C, Martín-Benito J, Moreno-Herrero F, Giraldo R, Llorca O.
Structure 2015 Jan 6; 23: 183. Published online 24 December 2014.
PubMed: 25543255. Doi: 10.1016/j.str.2014.11.007
Most available structures of amyloids correspond to peptide fragments that self-assemble in extended cross β sheets. However, structures in which a whole protein domain acts as building block of an amyloid fiber are scarce, in spite of their relevance to understand amyloidogenesis. Here, we use electron microscopy (EM) and atomic force microscopy (AFM) to analyze the structure of amyloid filaments assembled by RepA-WH1, a winged-helix domain from a DNA replication initiator in bacterial plasmids [….]
This article has been editorially commented: Bubeck D Structure 2015; 2310.
