Wang…Perálvarez-Marín {Sci Rep 6: 33776}

Helical unwinding and side-chain unlocking unravel the outward open conformation of the melibiose transporter. Sci Rep. 2016 Sep 23;6:33776. doi: 10.1038/srep33776.
Using a single-GPU workstation we have performed molecular dynamics simulations to understand the opening of the meilibiose permease of Escherichia coli as a paradigm of Na+/sugar symporters.