Category: Highlights2019

Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor. Nat Commun. 2019 Aug 8;10(1):3562. doi: 10.1038/s41467-019-11594-y.

Aug. 2019 / Highlights2019

26/09/2019

Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor

Eftekharzadeh B, Banduseela VC, Chiesa G, Martinez-Cristobal P, Rauch JN, Nath SR, Schwarz DMC, Shao H, Marin-Argany M, Di Sanza C, Giorgetti E, Yu Z,...

DNA specificities modulate the binding of human transcription factor A to mitochondrial DNA control region. Nucleic Acids Res. 2019 Jul 9;47(12):6519-6537. doi: 10.1093/nar/gkz406.

Highlights2019 / Jul. 2019

13/09/2019

DNA specificities modulate the binding of human transcription factor A to mitochondrial DNA control region

Cuppari A, Fernandez-Millan P, Battistini F, Tarres-Sole A, Lyonnais S, Iruela G, Ruiz-Lopez E, Enciso Y, Rubio-Cosials A, Prohens R, Pons M, Alfonso C, Toth...

Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13680-13689. doi: 10.1073/pnas.1900430116.

Highlights2019 / Jul. 2019

10/09/2019

Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology

Pittolo S, Lee H, Llado A, Tosi S, Bosch M, Bardia L, Gomez-Santacana X, Llebaria A, Soriano E, Colombelli J, Poskanzer KE, Perea G, Gorostiza...

Aggrescan3D (A3D) 2.0: prediction and engineering of protein solubility. Nucleic Acids Res. 2019 Jul 2;47(W1):W300-W307. doi: 10.1093/nar/gkz321.

Highlights2019 / Jul. 2019

06/09/2019

Aggrescan3D (A3D) 2.0: prediction and engineering of protein solubility

Kuriata A, Iglesias V, Pujols J, Kurcinski M, Kmiecik S, Ventura S. Nucleic Acids Res 2019 Jul; 47: W300. Protein aggregation is a hallmark...

Why are some Enzymes Dimers? Flexibility and Catalysis in Thermotoga Maritima Dihydrofolate Reductase. ACS Catal. 2019 Jul 5;9(7):5902-5911. doi: 10.1021/acscatal.9b01250.

Highlights2019 / Jul. 2019

06/09/2019

Why are some Enzymes Dimers? Flexibility and Catalysis in Thermotoga Maritima Dihydrofolate Reductase

Ruiz-Pernia JJ, Tuñón I, Moliner V, Allemann RK. ACS Catal 2019 Jul; 9: 5902. Dihydrofolate Reductase from Thermotoga maritima (TmDFHFR) is a dimeric thermophilic...

Structural basis for the inhibition of translation through eIF2α phosphorylation. Nat Commun. 2019 Jun 14;10(1):2640. doi: 10.1038/s41467-019-10606-1.

Highlights2019 / Jun. 2019

26/07/2019

Structural basis for the inhibition of translation through eIF2α phosphorylation

Gordiyenko Y, Llacer JL, Ramakrishnan V. Nat Commun 2019 Jun; 10: 2640. One of the responses to stress by eukaryotic cells is the down-regulation...

Highlights2019 / Jun. 2019

25/07/2019

A General Treatment to Study Molecular Complexes Stabilized by Hydrogen-, Halogen-, and Carbon-Bond Networks: Experiment and Theory of (CH2 F2 )n …(H2 O)m

Calabrese C, Li W, Prampolini G, Evangelisti L, Uriarte I, Cacelli I, Melandri S, Cocinero EJ. Angew Chem Int Ed Engl 2019 Jun; 58:...

Photoluminescence Activation of Organic Dyes via Optically Trapped Quantum Dots. ACS Nano. 2019 Jun 25;13(6):7223-7230. doi: 10.1021/acsnano.9b02835.

Highlights2019 / Jun. 2019

25/07/2019

Photoluminescence Activation of Organic Dyes via Optically Trapped Quantum Dots

Rodriguez-Rodriguez H, Acebron M, Iborra FJ, Arias-Gonzalez JR, Juarez BH. ACS Nano 2019 Jun; 13: 7223. Laser tweezers afford quantum dot (QD) manipulation for...

Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly. Nat Commun. 2019 Jun 28;10(1):2865. doi: 10.1038/s41467-019-10781-1.

Highlights2019 / Jun. 2019

25/07/2019

Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly

Cuellar J, Ludlam WG, Tensmeyer NC, Aoba T, Dhavale M, Santiago C, Bueno-Carrasco MT, Mann MJ, Plimpton RL, Makaju A, Franklin S, Willardson BM, Valpuesta...

Modulation of the helical properties of DNA: next-to-nearest neighbour effects and beyond. Nucleic Acids Res. 2019 May 21;47(9):4418-4430. doi: 10.1093/nar/gkz255.

Highlights2019 / May 2019

29/06/2019

Modulation of the helical properties of DNA: next-to-nearest neighbour effects and beyond

Balaceanu A, Buitrago D, Walther J, Hospital A, Dans PD, Orozco M. Nucleic Acids Res 2019 May; 47: 4418. We used extensive molecular dynamics...

Optical Control of Cardiac Function with a Photoswitchable Muscarinic Agonist. J Am Chem Soc. 2019 May 8;141(18):7628-7636. doi: 10.1021/jacs.9b03505.

Highlights2019 / May 2019

19/06/2019

Optical Control of Cardiac Function with a Photoswitchable Muscarinic Agonist

Riefolo F, Matera C, Garrido-Charles A, Gomila AMJ, Sortino R, Agnetta L, Claro E, Masgrau R, Holzgrabe U, Batlle M, Decker M, Guasch E, Gorostiza...

A Simple Approach to Design Proteins for the Sustainable Synthesis of Metal Nanoclusters. Angew Chem Int Ed Engl. 2019 May 6;58(19):6214-6219. doi: 10.1002/anie.201813576.

Highlights2019 / May 2019

18/06/2019

A Simple Approach to Design Proteins for the Sustainable Synthesis of Metal Nanoclusters

Aires A, Llarena I, Moller M, Castro-Smirnov J, Cabanillas-Gonzalez J, Cortajarena AL. Angew Chem Int Ed Engl 2019 May; 58: 6214. Metal nanoclusters (NCs)...

Category: Highlights2019

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