Category: Highlights2019

Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor. Nat Commun. 2019 May 2;10(1):2034. doi: 10.1038/s41467-019-09923-2.

Highlights2019 / May 2019

18/06/2019

Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

Escobedo A, Topal B, Kunze MBA, Aranda J, Chiesa G, Mungianu D, Bernardo-Seisdedos G, Eftekharzadeh B, Gairi M, Pierattelli R, Felli IC, Diercks T, Millet...

Loss of postnatal quiescence of neural stem cells through mTOR activation upon genetic removal of cysteine string protein-α.Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):8000-8009. doi: 10.1073/pnas.1817183116.

Apr. 2019 / Highlights2019

20/05/2019

Loss of postnatal quiescence of neural stem cells through mTOR activation upon genetic removal of cysteine string protein-alpha

Nieto-Gonzalez JL, Gomez-Sanchez L, Mavillard F, Linares-Clemente P, Rivero MC, Valenzuela-Villatoro M, Munoz-Bravo JL, Pardal R, Fernandez-Chacon R. Proc Natl Acad Sci U S...

Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8. Science. 2019 Apr 26;364(6438). pii: eaav9011. doi: 10.1126/science.aav9011.

Apr. 2019 / Highlights2019

20/05/2019

Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP gamma8

Herguedas B, Watson JF, Ho H, Cais O, Garcia-Nafria J, Greger IH. Science 2019 Apr; 364: eaav9011. AMPA-type glutamate receptors (AMPARs) mediate excitatory neurotransmission...

L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction. Nat Commun. 2019 Apr 18;10(1):1807. doi: 10.1038/s41467-019-09837-z.

Apr. 2019 / Highlights2019

20/05/2019

L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction

Errasti-Murugarren E, Fort J, Bartoccioni P, Diaz L, Pardon E, Carpena X, Espino-Guarch M, Zorzano A, Ziegler C, Steyaert J, Fernandez-Recio J, Fita I, Palacin...

Structural dynamics and transient lipid binding of synaptobrevin-2 tune SNARE assembly and membrane fusion. Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8699-8708. doi: 10.1073/pnas.1813194116.

Apr. 2019 / Highlights2019

15/05/2019

Structural dynamics and transient lipid binding of synaptobrevin-2 tune SNARE assembly and membrane fusion

Lakomek NA, Yavuz H, Jahn R, Perez-Lara A. Proc Natl Acad Sci USA 2019 Apr; 116: 8699. Intrinsically disordered proteins (IDPs) and their conformational...

Frozen-hydrated chromatin from metaphase chromosomes has an interdigitated multilayer structure. EMBO J. 2019 Apr 1;38(7). pii: e99769. doi: 10.15252/embj.201899769

Apr. 2019 / Highlights2019

14/05/2019

Frozen-hydrated chromatin from metaphase chromosomes has an interdigitated multilayer structure

Chicano A, Crosas E, Oton J, Melero R, Engel BD, Daban JR. EMBO J 2019 Apr; 38: e99769. Cryo-electron tomography and small-angle X-ray scattering...

Molecular Basis of Broad Spectrum N-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2. ACS Cent Sci. 2019 Mar 27;5(3):524-538. doi: 10.1021/acscentsci.8b00917.

Highlights2019 / Mar. 2019

02/05/2019

Molecular Basis of Broad Spectrum N-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2

Klontz EH, Trastoy B, Deredge D, Fields JK, Li C, Orwenyo J, Marina A, Beadenkopf R, Gunther S, Flores J, Wintrode PL, Wang LX, Guerin...

Predicting the Limit of Intramolecular Hydrogen Bonding with Classical Molecular Dynamics. Angew Chem Int Ed Engl. 2019 Mar 18;58(12):3759-3763. doi: 10.1002/anie.201810922.

Highlights2019 / Mar. 2019

29/04/2019

Predicting the Limit of Intramolecular Hydrogen Bonding with Classical Molecular Dynamics

Colizzi F, Hospital A, Zivanovic S, Orozco M. Angew Chem Int Ed Engl 2019 Mar; 58: 3759. The energetics of intramolecular recognition processes are...

DNA Crookedness Regulates DNA Mechanical Properties at Short Length Scales. Phys Rev Lett. 2019 Feb 1;122(4):048102. doi: 10.1103/PhysRevLett.122.048102.

Feb. 2019 / Highlights2019

20/03/2019

DNA Crookedness Regulates DNA Mechanical Properties at Short Length Scales

Marin-Gonzalez A, Vilhena JG, Moreno-Herrero F, Perez R. Phys Rev Lett 2019 Feb; 122: 048102. Sequence-dependent DNA conformation and flexibility play a fundamental role...

A Myristoyl-Binding Site in the SH3 Domain Modulates c-Src Membrane Anchoring. iScience. 2019 Feb 22;12:194-203. doi: 10.1016/j.isci.2019.01.010.

Feb. 2019 / Highlights2019

20/03/2019

A Myristoyl-Binding Site in the SH3 Domain Modulates c-Src Membrane Anchoring

Le Roux AL, Mohammad IL, Mateos B, Arbesu M, Gairi M, Khan FA, Teixeira JMC, Pons M. iScience 2019 Feb; 12: 194. The c-Src...

Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation. Nat Commun. 2019 Feb 22;10(1):907. doi: 10.1038/s41467-019-08796-9.

Feb. 2019 / Highlights2019

20/03/2019

Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation

Cabre G, Garrido-Charles A, Moreno M, Bosch M, Porta-de-la-Riva M, Krieg M, Gascon-Moya M, Camarero N, Gelabert R, Lluch JM, Busque F, Hernando J, Gorostiza...

Bacterial FtsZ protein forms phase-separated condensates with its nucleoid-associated inhibitor SlmA. EMBO Rep. 2019 Jan;20(1). pii: e45946. doi: 10.15252/embr.201845946.

Highlights2019 / Jan. 2019

28/02/2019

Bacterial FtsZ protein forms phase-separated condensates with its nucleoid-associated inhibitor SlmA

Monterroso B, Zorrilla S, Sobrinos-Sanguino M, Robles-Ramos MA, Lopez-Alvarez M, Margolin W, Keating CD, Rivas G. EMBO Rep 2019 Jan; 20: e45946. Macromolecular condensation...

Category: Highlights2019

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