Mompeán…Laurents {PLoS Biol 14: e1002447}
Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation
Mompeán M, Chakrabartty A, Buratti E, Laurents DV.
PLoS Biol 2016 Apr.; 14: e1002447.
TDP-43 is a protein that forms aggregates implicated in amyotrophic lateral sclerosis. In response to a recent study, this Formal Comment argues that the pH-dependent solubility of this protein is better explained by the mutual repulsion of charged groups than by the formation of hydrogen bonds.
PubMed: 27096426. Doi: 10.1371/journal.pbio.1002447.
