Melero…Llorca {Nat Commun 7: 10585}

The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation. Nat Commun. 2016 Feb 4;7:10585. doi: 10.1038/ncomms10585.
Model for the function of DHX34 in promoting UPF1 phosphorylation and NMD. DHX34 is recruited to the SMG1 kinase through a dedicated C-terminal domain (CTD), functioning as a scaffold that brings UPF1 (the substrate) and SMG1 (the kinase) together