Endosomal Trafficking: Retromer and Retriever Are Relatives in Recycling
Overview of transmembrane protein sorting in endosomes by retromer and retriever. The proposed model for retriever assembly was obtained combining the known structures of VPS29 and SNX17 with the calculated models of DSCR3 and C16orf62.
Gershlick DC, Lucas M.
Curr Biol 2017 Nov; 27: R1233.
Transmembrane proteins are sorted from endosomes to avoid lysosomal degradation. A recent study has identified a new multimeric complex called retriever that is essential for recycling numerous cell-surface cargoes from endosomes and is structurally and functionally related to the well-characterised retromer complex.
PubMed: 29161566. Doi: 10.1016/j.cub.2017.10.004.
