Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis

Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis. Nat Cell Biol. 2017 Jul;19(7):787-798. doi: 10.1038/ncb3559.
The endosomal sorting complex required for transport (ESCRT)-III mediates membrane fission in a variety of cellular processes such as cytokinesis, although the constriction mechanism remains elusive. Our in vitro and in vivo study on its dynamic assembly and disassembly suggests that the rapid turnover of the filament subunits is essential for membrane abscission during cytokinesis.