de Cima…Rubio {Sci Rep 5: 16950}

Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis. Sci Rep. 2015 Nov 23;5:16950. doi: 10.1038/srep16950.
Tunnel within human carbamoyl phosphate synthetase. This multi-domain enzyme, key for detoxifying ammonia as urea, makes carbamoyl phosphate in three steps (including two phosphorylations), uses two catalytic centres and requires allosteric control by N-acetylglutamate (NAG)