Darré…Orozco {JACS 138: 16355}

Small Details Matter: The 2'-Hydroxyl as a Conformational Switch in RNA. J Am Chem Soc. 2016 Dec 21;138(50):16355-16363. doi: 10.1021/jacs.6b09471.
A Lysine side chain can affect the orientation of the 2'-hydroxyl group in RNA, inducing a NORTH to SOUTH sugar puckering transition, which suggests a role of the 2'-hydroxyl moiety as a conformational switch involved in protein-RNA recognition.