Chen…Cremades {PNAS 112: E1994}

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation. Chen, et al. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E1994-2003. doi: 10.1073/pnas.1421204112.
Stable toxic α-synuclein oligomers of different sizes, β-sheet content and hydrophobicity can possess similar quaternary structure with remarkable similarities with amyloid fibrils. This suggests that the β-sheet geometry at incipient self-assembly can affect kinetic stability and toxicity