Albesa-Jové…Guerin {J Biol Chem 290: 31077}

The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053. J Biol Chem. 2015 Dec 25;290(52):31077-89. doi: 10.1074/jbc.M115.677039.
Schematic representation showing the catalytic motif of Rv2466c in close proximity to the alpha-helical subdomain. The C-terminus peptide of 13 amino acids binds to the active site and folds into an alpha -helix.