Solé…Felipe {J Cell Sci 129: 4265}

The C-terminal domain of Kv1.3 regulates functional interactions with the KCNE4 subunit.J Cell Sci. 2016 Nov 15;129(22):4265-4277. Epub 2016 Oct 6.
The voltage-gated potassium channel Kv1.3 functions during the immune response. Kv1.3, via its C-term, associates with the KCNE4 subunit which negative modulates the channel. Once KCNE4 interacts with Kv1.3, it retains the channel intracellular because impairs the COPII-dependent forward traffic and transfers a strong endoplasmic reticulum retention motif (ERRM) to the complex.