Photoexcitation of the P4(480) State Induces a Secondary Photocycle That Potentially Desensitizes Channelrhodopsin-2

Photoexcitation of the P4480 State Induces a Secondary Photocycle That Potentially Desensitizes Channelrhodopsin-2. J Am Chem Soc. 2018 Aug 8;140(31):9899-9903. doi: 10.1021/jacs.8b03931.
We have characterized the photocycle of the P4(480) intermediate of channelrhodopsin-2, and linked it to the secondary photocycle responsible for the desensitization and light-adaptation of the channel activity.