Pérez-Lara…Jahn {eLife 5: e15886}

PtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium. eLife. 2016; 5: e15886.
Synaptotagmin 1 binds to phosphatidylserine (PtdSer) via the Ca2+-binding sites and phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) via a polybasic lysine patch in the C2B domain.