Ortega…Millet {Chem Biol 22: 1597}

Halophilic Protein Adaptation Results from Synergistic Residue-Ion Interactions in the Folded and Unfolded States. Chem Biol. 2015 Dec 17;22(12):1597-607. doi: 10.1016/j.chembiol.2015.10.010.
Under high salt conditions, live is possible thanks to specific protein adaptations, allowing resistance to extreme osmolarity in the cellular cytosol. In this work we demonstrate that, in presence of ions, the uncommon aminoacid sequence of halophilic proteins favors their native conformation, against the unfolded state, through a synergistic mechanism of salt-induced stability.