Lórenz-Fonfría…Heberle {PNAS 112: E5796}

Temporal evolution of helix hydration in a light-gated ion channel correlates with ion conductance.Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5796.
Channelrhodopsins (ChRs) are light-gated ion channels used as optogenetic tools in neuroscience. By combining spectroscopic and electrophysiologycal experiments with microsecond resolution we show that light-induced cation permeation in ChR2 starts concomitantly with the hydration of transmembrane regions of the protein.