Iron-Based Core-Shell Nanowires for Combinatorial Drug Delivery and Photothermal and Magnetic Therapy
In this study, we have developed drug functionalized protein-coated iron nanowires as a new platform for Combinatorial Drug Delivery and Photothermal and Magnetic Therapy. The multifunctional capability of the new platform was explored for cancer cell destruction by combining the chemotherapeutic effect of drug functionalized nanowires with their optical and magnetic properties showing that the combinatory treatment resulted in nearly complete cancer cell death and was more effective than individual or bimodal strategies
Martinez-Banderas AI, Aires A, Quintanilla M, Holguin-Lerma JA, Lozano-Pedraza C, Teran FJ, Moreno JA, Perez JE, Ooi BS, Ravasi T, Merzaban JS, Cortajarena AL, Kosel J.
ACS Appl Mater Interfaces 2019 Nov; 11: 43976.
Combining different therapies into a single nanomaterial platform is a promising approach for achieving more efficient, less invasive, and personalized treatments. Here, we report on the development of such a platform by utilizing nanowires with an iron core and iron oxide shell as drug carriers and exploiting their optical and magnetic properties. The iron core has a large magnetization, which provides the foundation for low-power magnetic manipulation and magnetomechanical treatment. The iron oxide shell enables functionalization with doxorubicin through a pH-sensitive linker, providing selective intracellular drug delivery. Combined, the core-shell nanostructure features an enhanced light-matter interaction in the near-infrared region, resulting in a high photothermal conversion efficiency of >80% for effective photothermal treatment. Applied to cancer cells, the collective effect of the three modalities results in an extremely efficient treatment with nearly complete cell death ( approximately 90%). In combination with the possibility of guidance and detection, this platform provides powerful tools for the development of advanced treatments.
PubMed: 31682404. Doi: 10.1021/acsami.9b17512.
