Martinez-Banderas AI, Aires A, Quintanilla M, Holguin-Lerma JA, Lozano-Pedraza C, Teran FJ, Moreno JA, Perez JE, Ooi BS, Ravasi T, Merzaban JS, Cortajarena AL, Kosel J.
ACS Appl Mater Interfaces 2019 Nov; 11: 43976.
ombining different therapies into a single nanomaterial platform is a promising approach for achieving more efficient, less invasive, and personalized treatments. Here, we report on the development of such a platform by utilizing nanowires with an iron core and iron oxide shell as drug carriers and exploiting their optical and magnetic properties. The iron core has a large magnetization, which provides the foundation for low-power magnetic manipulation and magnetomechanical treatment. The iron oxide shell enables functionalization with doxorubicin through a pH-sensitive linker, providing selective intracellular drug delivery. Combined, the core-shell nanostructure features an enhanced light-matter interaction in the near-infrared region, resulting in a high photothermal conversion efficiency of >80% for effective photothermal treatment. Applied to cancer cells, the collective effect of the three modalities results in an extremely efficient treatment with nearly complete cell death ( approximately 90%). In combination with the possibility of guidance and detection, this platform provides powerful tools for the development of advanced treatments.
PubMed: 31682404. Doi: 10.1021/acsami.9b17512.