Egea-Jimenez…Zimmermann {Nat Commun 7: 12101}

Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling. Nat Commun. 2016 Jul 8;7:12101. doi: 10.1038/ncomms12101.
A. Crystal structure of the ternary complex of syntenin PDZ tandem with the C-terminal peptide (PDZ binding motif) from the Frizzled 7 receptor and PtdIns(4,5)P2 (PIP2). B. The PDZ2 domain of syntenin interacts with Frizzled 7 and PIP2 in a co-operative manner. C. Syntenin residues essential for PIP2 interaction supports the recycling of syntenin-Frizzled 7 complexes to the plasma membrane.