αCGRP is essential for algesic exocytotic mobilization of TRPV1 channels in peptidergic nociceptors
Devesa I, Ferrándiz-Huertas C, Mathivanan S, Wolf C, Luján R, Changeux JP, Ferrer-Montiel A.
Proc Natl Acad Sci USA. 2014 Dec 23; 111: 18345.
roalgesic sensitization of peripheral nociceptors in painful syndromes is a complex molecular process poorly understood that involves mobilization of thermosensory receptors to the neuronal surface. However, whether recruitment of vesicular thermoTRP channels is a general mechanism underlying sensitization of all nociceptor types or is subtype-specific remains controversial. We report that sensitization-induced Ca(2+)-dependent exocytotic insertion of transient receptor potential vanilloid 1 (TRPV1) receptors to the neuronal plasma membrane is a mechanism specifically used by peptidergic nociceptors to potentiate their excitability [….]