Copper(II)-Thymine Coordination Polymer Nanoribbons as Potential Oligonucleotide Nanocarriers
The direct reaction between copper nitrate, thymine- 1-acetic acid, and 4,4’-bipyridine in water leads to the formation of uniform crystalline nanoribbons of a coordination polymer. This polymer is able to interact with DNA structures bearing adenines and internalize into cells.
Vegas VG, Lorca R, Latorre A, Hassanein K, Gomez-Garcia CJ, Castillo O, Somoza A, Zamora F, Amo-Ochoa P.
Angew Chem Int Ed Engl 2017 Jan.; 56: 987.
The direct reaction between copper nitrate, thymine-1-acetic acid, and 4,4′-bipyridine in water leads to the formation of a blue colloid comprising uniform crystalline nanoribbons (length >1 mum; width ca. 150-185 nm; diameter ca. 15-60 nm) of a coordination polymer. The polymer displays a thymine-based structure freely available for supramolecular interactions. These nanostructures show significant selective interaction with single-stranded oligonucleotides based on adenine. Remarkably, they present low cell toxicity in three cell lines-despite the copper(II) content-and can be used as nanocarriers of oligonucleotides. These results suggest the potential of these types of nanostructures in several biological applications.
PubMed: 27936318. Doi: 10.1002/anie.201609031.
