Camunas-Soler…Ritort {Nucleic Acids Res 43: 2767}

Nucleic Acids Res. 2015 Mar 11;43(5):2767-79. doi: 10.1093/nar/gkv087
The binding sites of the anticancer drug Thiocoraline onto DNA are detected with one base pair resolution by unzipping a single DNA molecule with optical tweezers, and looking at the mechanical footprint of binding (force-extension curve in red).