Allosterism and signal transfer in DNA

Allosterism and signal transfer in DNA. Nucleic Acids Res. 2018 Sep 6;46(15):7554-7565. doi: 10.1093/nar/gky549.
Secondary protein of allosteric couple binding to free and effector-bound DNA at different distances from BAMHI effector protein binding site. Signal transfer through DNA between the binding sites of the two proteins is achieved by transient propagation of structural fluctuations without change in the equilibrium structure of the DNA. Depending on the distance between the two binding regions, the signal phase can either favor or disfavor cooperativity through correlated atomic fluctuations and entropy penalty change.